Research Antibiotics, Tylosin Tartrate, 1 gram

Tylosin Tartrate, 1 gram. Tylosin tartrate is a macrolide antibiotic that was originally isolated from Streptomyces fradiae by the Lilly Research Laboratories in 1961 from a soil sample collected in Thailand. Tylosin is a mixture of four macrolide antibiotics, the main component of the mixture (> 80%) is tylosin A; tylosin B (desmycosin), tylosin C (macrocin), and tylosin D (relomycin) may also be present. Tylosin has broad spectrum bacteriostatic activity against gram-positive bacteria and mycoplasma, but much less activity against most gram-negative bacteria and fungi.

Tylosin, like other Macrolide antibiotics, is a bacteriostatic compound that reversibly bind to the 23S rRNA in the 50S (L27 protein) ribosome subunit and inhibit mRNA-directed protein synthesis.

Tylosin has been used to study protein synthesis, abscess prevention in cattle, and Mycoplasma infections.

• Category: Microbiology
• CAS Number: 74610-55-2
• Molecular Formula: C46H77NO17 · C4H606
• Molecular Weight: 1066.18 g/mol
• Mechanism of Action: Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to tylosin tartate is commonly attributed to mutations in 50S rRNA preventing tylosin tartate binding allowing the cell to synthesize proteins free of error.
• Storage Conditions: ≤30°C
• Tariff Code: 2941.90.1010
• Spectrum: Tylosin tartate targets primarily gram positive bacteria and species of the Mycoplasma genus.

Microbiology Applications

Tylosin tartate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

Mycoplasma hyopneumoniae 0.015 µg/mL – 0.3 µg/mL
Streptococcus pneumoniae 0.125 µg/mL - 64 µg/mL

Specifications

• Form: powder
• Appearance: white to slightly yellow powder
• pH: 5.0-7.2
• Assay (on dried basis): Not less than 800 IU/mg
• Loss on Drying ≤4.5%
• Sulfated Ash ≤2.5%
• Impurities Tyramine: ≤3.5%

References

Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome. "Journal of Molecular Microbiology 330.5 (2003): 1005-014.

Available Documents

• SDS
• Product Data Sheet
• Susceptibility and Resistance Data

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.