Research Antibiotics, Telavancin Hydrochloride, 10mg

Telavancin Hydrochloride, 10 mg. Telavancin Hydrochloride is the hydrochloride salt of Telavancin, a lipoglycopeptide antimicrobial that has bactericidal activity against Gram-positive bacteria including MRSA. It was derived from Vancomycin, and has superior in vitro activity against glycopeptide-susceptible organisms.

• Category: Microbiology
• CAS Number: 560130-42-9
• Molecular Formula: C₈₀H₁₀₇Cl₃N₁₁O₂₇P
• Molecular Weight: 1792.10
• Mechanism of Action: Telavancin inhibits the synthesis of bacterial cell walls by binding to the D-Ala-D-Ala terminus of the peptidoglycan in the growing cell wall. It also disrupts bacterial cell membrane potential and permeability since the lipophilic moiety of the compound may interact with the lipid bilayer in the membrane.
• Storage Conditions: -20°C
• Spectrum: Effective against Gram-positive bacteria such as MRSA, VISA and hVISA strains of S. aureus.

Microbiology Applications

Telavancin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.

Representative concentration ranges include:

Staphylococcus aureus (methicillin-resistant) 0.06-0.5 μg/ml
Streptococcus pneumonia (penicillin-resistant) 0.015-0.03 μg/ml

Specifications

• Form: Powder
• Appearance: White to off-white solid
• Source: semi-synthetic

References

Damodaran SE and Madhan S (2011) Telavancin: A novel lipoglycopeptide antibiotic. J. Pharmacology Pharmacother. 2(2):135-137 PMID 21772784

Higgins DL (2005) Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 49 (3):1127-1134

Jansen WT, Verel A, Verhoef A and Milatovic D (2007) In vitro activity of telavancin against Gram-positive clinical isolates recently obtained in Europe. Antimicrob. Agents Chemother. 51:3420–3424 PMID 17606689

Ruggero MA, Peaper DR and Topal JE (2015) Telavancin for refractory methicillin-resistant Staphylococcus aureus bacteremia and infective endocarditis. Infect. Dis. (Lond) 47(6):379-384 PMID 25746601

Available Documents

• SDS-EU
• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.